Introduction to Nootropics
Introduction to Nootropics
The word nootropics was first used by a Romanian chemist Corneliu Giurgea in the year 1970 for describing substances capable of enhancing/regaining the cognitive functions among humans.
According to him typical characteristics of nootropics include an enhancement in learning capability; coping with stressful environments; neuroprotection for proper nerve transmission and should be non-sedative.
Better cognitive performance of an individual is linked with overall successes in life, execution of job-related functions, and well-being in society.
By improving the brain functions through nootropics improve several cognitive functions like enhanced memory, creativity, being sharp and quick in decision making. Mainly there are three categories of nootropics including:
- Dietary items
- Supplements, and
- Prescription items.
The dietary ingredients include caffeine in certain drinks like tea, coffee, and brain-boosting ingredients in mushrooms. In the supplement category, Noopept stands out due to its fast action.
The majority of cognitive performance enhancer medications are slow in their effect, and the one having a quick response is preferred. There are several prescription nootropics also including Concerta, Ritalin, and Adderall. We are living in a highly dynamic world.
Particularly, competition at job place and business environments demand higher levels of cognizance and intellect.
Global surveys suggest young generation has cognitive issues across the globe. A person with a healthy cognitive function is overall beneficial in society.
This scenario has generated a quest for better cognitive abilities among everyone. According to the data released by Barnes and Noble the famous specialty bookseller people’s inclination has changed toward acquiring literature related to emotional and mental health-relevant subjects. This trend suggests a higher public interest in nootropics.
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Ideal Characteristics of a nootropic
An ideal nootropic should have an affinity for accessing the brain upon getting ingested. The human brain controls all cognitive functions including every activity that we perform on a daily basis.
For achieving its functions to the highest accuracy and efficiency, the brain is shielded with a structure known as the blood-brain barrier. This brain shielding structure separates and protects the brain from harmful ingredients in the systemic circulation.
Naturally, the brain has affinity and transport mechanisms for the passage of components having beneficial effects on brain functions.
Appropriate delivery of nootropics into the brain is considered the most desirable feature for its clinically helpful effects. For example, in the development of Noopept, it was evaluated for its penetration through the BBB. Scientific data suggested that upon absorption through the gastrointestinal tract this compound is delivered to the brain in its intact form.
How do nootropics work?
Among several available nootropics, everyone has its specific mechanism of action. However, an ideal nootropic must facilitate nutrient supply and their proper utilization in the brain. The human brain utilizes almost 20% of the overall energy even in resting conditions.
This may enhance when we are exerting more pressure on the brain like doing some task that needs continuous cognitive function involvement. Besides consolidating the utilization of energy within the brain nootropics should be capable of enhancement in cognitive functions like elevated memory, improved learning process, and retrieval of both short-term and long-term memory.
A variety of nootropics available in the market exert their effects through several mechanisms including lowering of malondialdehyde levels with a concomitant increase in the antioxidant brain defense system mediated through biological molecules like glutathione and superoxide dismutase.
Besides this modulation of NMDA receptor, inhibition of glutamate-induced toxicity and acetylcholinesterase activity, normalizing noradrenaline levels and turnover of monoamines, and controlling the activity of dopamine-D2 and GABAB receptors are few to name here.
A nootropic exerts its cognitive function enhancement or neuroprotective effect by employing either one or a combination of these mechanisms.
When to Use Nootropics Elderly population
The usage of nootropics varies based on individuals’ age, health condition, and work environments.
Mainly, elderly individuals are prone to cognitive decline associated with aging. Advanced age is associated with decreased absorption of natural nootropics and as such supplements containing nootropics can boost the cognitive capabilities of these individuals.
In a population-based study involving above twelve thousand elderly individuals evaluated over a time period of ten years suggested that nootropics enhance cognitive abilities. Benefits associated with nootropics include reduced mortality, lower incidence of degenerative and vascular dementia among these individuals.
The usage of nootropics has been recommended in several conditions among people suffering from cognitive deficits like memory and learning problems, overcoming several depressive syndromes, anxiety, and tension that compromise human cognition.
Nootropics have also been reported to improve social and technical skills. The nootropics-based enhancement in cognitive abilities is also manifested in the form of better communications and effective use of language for academic, social, and general writing and speaking pursuits.
Nootropics in Neurodegenerative Disorders
The nootropics horizon is expanding from simply brain booster or memory-enhancing formulation to treat brain disorders in which people lose cognitive abilities.
An extensive study has identified a variety of nootropics exerting their effects through one of the several mechanisms like acting as calcium channel blockers, acetylcholinesterase inhibition, overcoming oxidative stress, and antagonizing dopaminergic and glutamic acid receptors.
A comprehensive evaluation of clinically relevant studies shows that nootropics will be the likely and safer choice for the treatment of diseases like Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. A few nootropics exert their effect through several ways aimed toward enhancing cognitive functions.
Noopept protects neuronal cells through its effect like inhibiting oxidative damage exerted through oxygen-free radicals, regulating calcium levels, suppression of apoptosis, and ameliorating neural dysfunction induced by Aβ25-35.
Every human being is born with defined cognitive capabilities and performances. However, several factors can compromise cognitive functions.
These include nutritional as well as non-nutritional factors. Specific ailments also contribute to deteriorating cognitive capacities. As such nootropics repair and restore the innate cognitive functions and make people smart.
Besides this, nootropic put the brain’s physiological functions on the right track. It is exactly like you have a good teacher who can assist you in becoming a top-notch student when compared with your contemporary age fellows.
Nootropics refine your brain functions by improving and accelerating human cognitive functions.