Noopept – The Scientific Guide
Noopept enhances the cognitive functions besides its neuroprotective characteristics. This compound belongs to a family of therapeutic drugs known as nootropics – memory and cognitive function enhancers. The discovery of Noopept is quite miraculous involving psychotropic drug discovery. The prototype of Noopept is a drug known as Piracetam. However, pharmacologically, it is a thousand times more potent than its prototype besides exerting a potent neuroprotective and anxiolytic characteristic.
Initial studies showing the nootropic effects of Noopept ensued several scientific studies. Interestingly, scientists have been more interested to know, how this drug enhances the cognitive function in the human being. Worth mention here are several pre-clinical studies showing the benefits of Noopept. However, crucial information about the benefits of this formulation was gleaned out through a comparative study in which Noopept proved its superiority over the piracetam in treating patients suffering from cognitive disorders (1).
The benefits of Noopept
The nootropic effect of Noopept is mediated through a variety of mechanisms proved through scientific studies. Among several, a few worth mentioning related to Noopept benefits are:
- Enhancing the production of nerve growth factor and brain-derived neurotrophic factors in the hippocampal region.
- Promoting choline generation.
- Reduction in the oxidative stress through controlling the production of free radicals.
- Repressing biomolecules associated with the induction of stress responses in the brain.
- Neuroimmunomodulation – strengthening the brain for its protection mechanisms from diseases and infections.
All the above-described characteristics of Noopept are essential for enhancing cognitive and memory functions. Although Noopept possesses beneficial effects in a variety of neurogenerative disorders, however, scientific studies have mainly focused on limited diseases.
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Noopept as a possible treatment agent
Following is a brief about the Noopept mediated brain disorders treatments opportunities:
Treatment of Alzheimer’s Disease, multiple sclerosis, Parkinson’s disease, major depressive syndrome, neuropsychiatric and Neurodegenerative Disorders with Noopept – the Ultimate Mechanisms
Enhancing levels of NGF and BDNF
It has been proved scientifically that Noopept increases the levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) (2). A significant increase in the levels of both these beneficial proteins was observed in the area of the brain known as the hippocampus, a region of the brain involved in cognitive functions among humans. Importantly, both these biomolecules improve brain functioning.
The NGF has been described to act as nourishing material for neurons in performing their physiological function, whereas numerous benefits of BDNF has been described ranging from improving learning and memory functions through several mechanisms including the formation of healthy neurons, protecting neural dendritic processes involved in synaptic transmission besides overall healthy brain functions.
The BDNF boosting effects of Noopept suggest its benefits in several other psychiatric and neurodevelopmental diseases besides its efficacy as an antidepressant and antipsychotic potentials. Among specific disease where Noopept mediated benefits can provide the healing effect are: addiction, major depressive disorders, schizophrenia, and Rett syndrome deeply linked with reduced BDNF (3).
There is substantial proof of the concept that in diseases like Huntington’s diseases, multiple sclerosis, and Parkinson’s diseases there is a reduction in the production of BDNF within the brain. The Noopept mediated BDNF boosting effect is recognized as curative for these neurodegenerative ailments. Although, clinical studies need to be conducted for its appropriate approvals, however, based on its beneficial effects and the recognition of
Noopept as a safer dietary ingredient the potential of these useful products are enormous.
Noopept is cheap…
Importantly, in comparing the relative cost, the Noopept is available at a relatively lower cost when compared with its parental drug Piracetam that need to be taken in relatively higher amounts that stressing the body systems including liver and kidney.
It has become a fact that Alzheimer’s disease is associated with the formation of plaques in the human brain mainly comprised of amyloid beta (Ab). Majority of drugs for the treatment of this disease focuses on the reduction of amyloid plaques. In the Alzheimer’s model, Noopept not only reduced the plaques forming amyloid instead it also provides neuroprotection through several other mechanisms involving reduction of tau hyperphosphorylation and enhancement of mitochondrial potential necessary for fulfilling energy requirements of neuronal cells (4).
Other possible uses of Noopept
The drug may have many different uses. Studies were reviewed – they are referenced in the reference section.
Modulation of Acetylcholine by Noopept
Noopept has been proved to modulate the acetylcholine level in the brain. The acetylcholine along with glutamate has been reported to not only protect the brain from damages rather it enhances cognitive functions, memory, learning skills besides relieving anxiety (2).
Noopept overcomes the production of free radicals causing oxidative stress and neural damage.
The onset and progression of neurodegenerative ailments and neural deficits are associated with the production of free radicals in the brain that generates oxidative stress. The Noopept has been reported to reduce the oxidative stress in the brain ailments and protect the neural transmission processes. Several scientific studies have confirmed that in neuronal cell culture models Noopept decreased oxidative stress (5).
Noopept protects the brain and enhances cognitive functions through neuroimmunomodulatory effects
The immunopharmacological properties of the Noopept have also been linked with protecting the human brain and elevating cognitive functions. It has been reported that Noopept brain protective mechanisms are supplanted with activation of both humoral and cellular immune responses including enhancing proliferation of cells involved in toxic substances and infectious agents control besides increasing phagocytic capability of cells involved in general and neuroprotective mechanisms (6).
Based on all the above scientific pieces of evidence it is easy to conclude that Noopept is one of the safest and most effective nootropics. This formulation besides strong scientific support is also water soluble having enhanced bioavailability and quick pharmacological action.
If you or your loved one is suffering from any neurological ailment and issues with learning, short term, and long term memory issues, Noopept is the choice for controlling such neuronal illnesses.
Personal experiences and uses
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1. Neznamov GG, Teleshova ES. Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. Neurosci Behav Physiol. 2009;39(3):311-21.
2. Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, et al. Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bull Exp Biol Med. 2008;146(3):334-7.
3. Autry AE, Monteggia LM. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev. 2012;64(2):238-58.
4. Ostrovskaya RU, Vakhitova YV, Kuzmina U, Salimgareeva M, Zainullina LF, Gudasheva TA, et al. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci. 2014;21:74.
5. Vakhitova YV, Sadovnikov SV, Borisevich SS, Ostrovskaya RU, T AG, Seredenin SB. Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept. Acta Naturae. 2016;8(1):82-9.
6. Kovalenko LP, Shipaeva EV, Alekseeva SV, Pronin AV, Durnev AD, Gudasheva TA, et al. Immunopharmacological properties of noopept. Bull Exp Biol Med. 2007;144(1):49-52.