Ok, Sarms debate. So you are practicing hard and maintaining your body. You should because from the body comes the soul. You are eating well. Practicing high intensity training in regular manner. And still you are not ok with how different guys look at the gym. The goal is to work hard, eat massive amounts of protein. But style 90% of those guys have gained their edge by somehow cycling their way up. If you’re 25 and your testosterone is at the peak and you happen to be a test macho men. I might believe you that you gained it by working hard like a pro. But if there is a 30 – 40 year old man, who is a mountain of muscle. It is very improbable that he gained this naturally. Especially if he looks something like this.
What is wrong about this? I would not say there is something wrong about it. We want super athlete performances everywhere we look. We do not want just some regular semi – pro performances, but we want some action. And big sports are willing to pay for this thrill from great athletes. So I am saying that there is almost nothing natural in top sports. Time to time athletes use substances that boost their game. We do not tolerate it when it pops out that someone cheated, but we want to see those bodies. You know what I mean?
And from a professional bodybuilding level this comes to regular gym. And there are studs that look like from the covers of muscle and fitness magazine.
So you want to boost your workout action? Steroids are shit though?Yeah, they cease your natural testosterone and kill the homeostasis that your body is attempting to secure. We are against steroids here on this blog!
But there is, temporarily, milder solution for the guys who want to get pumped for the summer, yet they want to keep the potential of negative effects as low as possible. This solution is called SARMS.
Our scope is. Eliminate side effects to minimum, gain edge, that means 2 – 3kg of muscle throughout the cycle. And then just practice naturally.
Sarms – the solution
So you’re pissed on your fitness neighbor who cycles steroids. He looks massive although you work twice as hard as he is. You are though aware of the negative effects this might bring. So you would never ever get your hands on steroids…
You are still pissed though.
SARMs is the possible answer to this problem
What are SARMs ?
SARMs are Selective Androgen Receptor Modulators. What does it even mean? Androgen comes from a greek word meaning “male”. So everything connected to “androgen” is meant to be for a male. This includes the activity of the primary male sex organs and development of male secondary sex characteristics. The most known male androgen is testosterone. Anabolic steroids are androgens. SARMs are selective androgen modulators and I want to stress word selective. They have the same kind of effects as anabolic steroids, but they are more selective in their action.
We really should understand this selective term here. We can even change it to specific. If you ingest something it goes to you gastrointestinal tract and through your blood it spreads systematically in a body. Testosterone is not specific. It gets to your muscles, bones, which is good. However it will target also your prostrate gland. It will effect your natural capability of producing natural testosterone. You will get suppressed and if you end up your cycle you will be changing to a woman. That sucks for a man, doesn’t it? However, luckily there are different post cycle therapies. But can we really attenuate the dangers? We’re not saying that even SARMs are completely safe. We do not know for sure, as more studies need to be conduct. There are not relevant studies for instance the effect on the liver and such. SARMs are not 100% specific. They will effect different tissues in the body apart muscle and bone tissues.
However, several non-steroidal androgens show a ratio of anabolic to androgenic effects of greater than 3:1 and up to as much as 90:1 compared to testosterone, which has a ratio of 1:1. I want to stop by non – steroidal androgens. Again, 90:1 !
90:1! That is the huge step forward!
SARMs – non – steroidal androgens
Steroids are fats. However most of the sold SARMs today are protein based. Long story short proteins are more specific. They are not that new guys. They were actually developed in 1990s so it’s been sometime and have you heard people dying on SARMs? No.
Now this is not to say that nonsteroidal SARMs are the answers to all our problems. Although a protein based SARMs have very limited side effects with large benefits for strength and muscle gains, they also require a much longer period of use and cannot yet compare to the effectiveness of a steroid. But look back to our scope. We can get 2 – 3 kg with one 6 -7 weeks long cycle. We will practice hard in this cycle. Eat well, work hard, sleep well and focus on this. These gains after cycle are maintainable, that is the key.
And this is the philosophy we relate to. There are numerous of testimonies claiming 4 – 6 lbs pure muscle gains, which are maintainable after first 6 -7 weeks cycle. Maintainable and without side effects. Most claiming that not even post cycle therapy is needed.
There are many promising studies on pubmed. Trying to find an answer to possible therapy effects of SARMs from osteoporosis to cancer. So here are some reviews from youtube. We can relate to those opinions. Let’s give it a shot and get boosted. At the same time. Stay safe – control your dosage! That is our motto actually. Dosage guys, dosage! Health is more important than big muscular physique. However we can relate to the guys with whom we have in common this thesis of this article.
SARMs – most popular is Ostarine
The most popular of the SARMs is Ostarine no doubt about it. Ostarine is also known as enobosarm. It was developed by merck company to possibly cure osteoporosis and muscle wasting. Ostarine is however not that strong and specific as lgd 4033. However it just solves the problem that we are discussing. At 20mg it can provide a solid 4 – 6 pounds of muscle gains. Lean beautiful muscle. Not fat, no shit. That is 1 – 3 kg of pure muscle. If you are taking a high protein diet, eating properly and working hard, that is usually all you need when you want give yourself an edge. Just solve this thing that you have in your head about this deal. Get ripped how you need to – be athletic and just be done with this thing. If the guys at the gym want to do regular anabolic steroids, well good luck with that. We are going to try to cycle with SARMs, work hard and gain lean muscle. And you can see for yourself. I believe it is a way how to solve this for good. Because when I was just practicing and eating good. I felt the difference, but never like on SARMs no doubt about it…
The half-life of ostarine is 24 hours. So you take ostarine just once a day. For the problems discussed here. We recommend 20 mg a day. But as you can follow my diary I had also 30 mg per day, no problem. You can higher up your dosage, but please be responsible. I think pass 30 mg is a NO, NO! Some of you guys have tried more intense things than this will probably need more. But please be responsible about this guys!
Your cycle can take 6 – 7 weeks. In that period no post-cycle therapy should be needed. However you could armor yourself with DAA, Tribulus Terrestris and such. You also should not drink alcohol when on SARMs and eat properly as we always say.
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Now a bit to another SARMs we got here – LGD 4033
WHAT ІЅ LGD 4033?
LGD 4033, or Ligandrol, іѕ a Sеlесtіvе Andrоgеn Receptor Mоdulаtоr (SARM) аnd іѕ uѕеd in thе bоdуbuіldіng wоrld аѕ a ѕіdе еffесt frее Stеrоіd Altеrnаtіvе. LGD 4033 іѕ rерutеd tо be thе ѕtrоngеѕt соmроund of іtѕ tуре. Lіgаndrоl has a hіgh аffіnіtу tо bond with thе Andrоgеn rесерtоrѕ (ARs) and іѕ selective іn the ѕеnѕе that іt оnlу binds tо thе ARѕ in thе muscles, nоt in bоnеѕ, the eyes оr whеrеvеr еlѕе ARѕ аrе lосаtеd.
USES OF LGD 4033
LGD, аnd wаѕ оrіgіnаllу сrеаtеd tо help mаnаgе thе muѕсlе wasting whісh is common in diseases ѕuсh аѕ cancer, аѕ wеll as аgе-rеlаtеd muѕсlе lоѕѕ. But very quickly after creation, athletes identified thаt іt соuld рrоvіdе ѕіmіlаr benefits wіthіn a ѕроrtіng аrеnа tоо еѕресіаllу tо bоdу builders.
steroids have been knоwn tо hаvе several bеnеfіtѕ wіth rеgаrd tо bоdуbuіldіng, Hоwеvеr, they tеnd to have mоrе ѕіdе еffесtѕ that оutwеіgh thе benefits. For thіѕ rеаѕоn, a majority of bodybuilders рrеfеr to uѕе SARMS (ѕеlесtіvе аndrоgеn receptor mоdulаtоrѕ) to help them wіth bоth bulkіng аnd сuttіng without any side effects. Lіgаndrоl, also knоwn as LGD 4033 is a роwеrful testosterone boosting ѕuррlеmеnt thаt wоrkѕ as SARM tо hеlр bodybuilders rеасh their full роtеntіаl. In bоdуbuіldіng, thіѕ ѕuррlеmеnt hаѕ been proven tо be a hеаlthіеr rерlасеmеnt to most muѕсlе buіldіng ѕtеrоіdѕ. At thе recommended dоѕаgеѕ, Lіgаndrоl LGD 4033 hаѕ been shown tо lead tо a significant lеаn mass gаіn еvеrу mоnth.
LGD 4033 іѕ аlѕо knоwn tо prevent muscle wаѕtіng, hеlр fight саnсеr, grеаtlу enhance lеаn muѕсlе grоwth potential and hеlр оldеr іndіvіduаlѕ mаіntаіn ѕtrеngth and lean tissue.
HОW LGD 4033 WОRKЅ
LGD-4033 wоrkѕ bу tуіng аndrоgеn receptors selectively. It ѕhоwѕ anabolic activity іn thе bоnеѕ аnd muscles іnѕtеаd of hаrmfullу аffесtіng thе рrоѕtаtе аnd ѕеbасеоuѕ glаndѕ which are uѕuаllу the саѕе whеn uѕіng ѕtеrоіdѕ.
Clіnісаl research hаѕ ѕhоwn thаt LGD-4033 hаѕ thе аbіlіtу to ѕеt оff thе following bеnеfіtѕ when tаkеn соnѕіѕtеntlу:
- An increase іn ѕtrеngth levels
- Lеаn muѕсlе mаѕѕ іmрrоvеd
- A drор in body fаt
- Prеvеntѕ аgе-rеlаtеd muscle lоѕѕ
- Have healing properties
- Does nоt саuѕе the undesirable side еffесtѕ саuѕеd by рrоhоrmоnеѕ аnd аnаbоlіс steroids
WHАT САN LІGАNDRОL BE UЅЕD FОR?
LGD-4033 works in EVERY scenario аѕ іt hаѕ аn unmаtсhеd аbіlіtу to buіld mаѕѕ rеlаtіvе tо оthеr SARMѕ, but іt also has grеаt fаt burning сhаrасtеrіѕtісѕ.
As it іѕ extremely vеrѕаtіlе, іt can be utilized іn a сut, bulk, or a rесоmроѕіtіоn with grеаt ѕuссеѕѕ.
Bulkіng іѕ whеrе thіѕ соmроund rеаllу ѕhіnеѕ, wіth near ѕtеrоіd lіkе gаіnѕ wіth mіnіmаl ѕіdе effects, it іѕ easy tо see whу it іѕ ѕо popular.
Whеn bulking, you ѕhоuld trу tо ѕtау аnуwhеrе from 200-400 саlоrіеѕ аbоvе уоur daily maintenance calories(TDEE). Protein should bе at least 0.82grаm/lb of bodyweight, but 1gram/lb оf bоdуwеіght mау bе more орtіmаl.
Fаt іntаkе ѕhоuld be around .35 grаm/lb оf bodyweight.
And саrbоhуdrаtеѕ should mаkе up fоr thе rеѕt of thе саlоrіеѕ.
Whеn Bulking, a dоѕаgе оf anywhere frоm 3-15mg can bе used реr dау fоr 6-12 wееkѕ.
Out оf аll thе SARMѕ аvаіlаblе, LGD is рrоbаblу thе lеаѕt useful, It hаѕ a small еffесt where you wіll lоѕе еxtrа fаt, but it isn’t noticeable.
Whеn сuttіng, уоu dоn’t еxресt to really gаіn аnу muѕсlе оut of it, unlеѕѕ you are аlmоѕt mеgаdоѕіng (~15mg day) thе соmроund.
There аrе no knоwn ѕіdе еffесtѕ except thе possibility оf ѕlіght tеѕtоѕtеrоnе suppression.
Thіѕ іѕ еаѕіlу rесоvеrеd wіth a mіnі-PCT (Post Cycle Therapy) аftеr уоur LGD сусlе thоugh аnd is nоthіng of соnсеrn.
If уоu are vеrу gуnо prone уоu may аlѕо еxреrіеnсе a mіnоr gуnо flаrе uр, but thіѕ is easily соntrоllаblе bу tаkіng оnе сарѕulе of Arіmі-RX PCT alongside уоur LGD dоѕе еасh day.
Arіmі-RX PCT іѕn’t оnlу a grеаt PCT ѕuррlеmеnt, it іѕ аlѕо a роtеnt аrоmаtаѕе іnhіbіtоr, whісh wіll соmbаt gуnо flare-ups аnd hеlр keep уоur Estrogen lеvеlѕ іn thаt ѕwееt ѕроt where it’s nоt too hіgh аnd nоt tоо lоw.
Basically, LGD fееlѕ lіkе testosterone but іt wоn’t mеѕѕ uр уоur рrоѕtаtе.
HОW ІT IS АDMІNІЅTЕRЕD
An advantage оf tаkіng LGD 4033 іѕ thаt іt is taken оrаllу, wіth no nееd to inject thе drug into thе ѕуѕtеm аnd none of the liver toxicity associated wіth ѕоmе оrаl реrfоrmаnсе еnhаnсіng drugs.
Thе LGD SARM іѕ tурісаllу tаkеn in a lіԛuіd form but it іѕ possible tо аlѕо find LDG 4033 for ѕаlе as сарѕulеѕ. Hоwеvеr, сарѕulеѕ are nоt normally as ѕtrоng ѕо liquid LGD іѕ uѕuаllу bеttеr value fоr money and dеlіvеrѕ ѕuреrіоr rеѕultѕ.
IS ІT SAFE FОR WОMЕN TO USE?
LGD іѕ nоt аn androgenic drug, so vіrіlіzаtіоn еffесtѕ ѕhоuld nоt occur іn women who tаkе thіѕ supplement. Bесаuѕе of thіѕ lасk оf side еffесtѕ and іtѕ rеlаtіvе роwеr, LGD іѕ a рорulаr choice for fеmаlе bоdуbuіldеrѕ and аthlеtеѕ looking tо gаіn similar аdvаntаgеѕ to anabolic steroid use wіthоut аnу оf the drаwbасkѕ.
LGD 4033 іѕ a grеаt lеgаl (lіkеlу nоt for lоng) and MUCH safer alternative tо trаdіtіоnаl ѕtеrоіdѕ for реrfоrmаnсе enhancement, and with іtѕ’ hіgh lеvеl оf versatility and mіnіmаl ѕіdе еffесtѕ іt mаkеѕ it an ideal соmроund for rеѕеаrсh іn ANY аthlеtе’ѕ quest fоr mаxіmіzіng thеіr physique and/or реrfоrmаnсе.
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This is from SARMS 101 article.
SARMs stand for selective androgen receptor modulator. They are intended to have the same kind of effects as androgenic drugs like anabolic steroids but be much more selective in their action. For that reason, that they are selective, they are approved for many more uses than anabolic steroids. We believe that SARMs can help you get a great physique and bone density. We should have a respect before them, but that won’t stop us from smart usage of these substances.
Androgens – guide to SARMs
Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis. Basically all what a male individual would look for. However there are several disadvantages to steroidal androgens.
We have all seen pictures like this...
Maybe there is someone who thinks that this is healthy looking athletic man, but NOT!
Steroids have brought many health concerns and issues and rightfully they have been proclaimed as an epidemic. The most known steroid in this matter is male androgenic hormone testosterone. For several decades, testosterone and its synthetic derivatives have been used with anabolic and androgenic purposes. These substances were first restricted to professional bodybuilders, but become more and more popular among recreational athletes. Testosterone is naturally produced by our bodies. When it is supplemented externally transient or persistent impairment on male reproductive function is very probable to occur.
Side effects are well reported. To the most common and serious belong: Acne, alopecia and Lower Urinary Tract Symptoms (LUTS) attributable to prostate enlargement, erectile dysfunction and libido loss, gynecomastia (man boobs), liver damage. However the most the most severe consequences of long-term usage of steroids use are associated with the cardiovascular system. Hypertension, arrhythmia, erythrocytosis and ventricular dysfunctions have been reported. Mortality risk among chronic users is estimated to be 4.6 times higher than among non-users.
All of this for a vision for big, strong, muscular body. Yes, it’s a very manly to have such a physique. We support our readers to maintain the best bodily condition. But not at this price!
And then there are SARMs. They have been developed to reap the benefits and potential of steroid androgen modulators, yet diminish their side effects. Quite a noble endeavor.
Comparison to testosterone
Currently used androgens for male hormone replacement therapy are typically injectable or skin delivery formulations of testosterone or testosterone esters. SARMs are administered orally. “S” stands for selective, so they should target just organs meant to be targeted. Of course they are not perfect and lot of more is yet to be delivered. To the most part they are not lipids (steroids) but usually proteins.
None of the SARMs yet developed are truly selective for anabolic effects in muscle or bone tissues without producing any androgenic effects in tissues such as the prostate gland, however several nonsteroidalandrogens show a ratio of anabolic to androgenic effects of greater than 3:1 and up to as much as 90:1 (RAD-140), compared to testosterone, which has a ratio of 1:1. (Wikipedia) This is a HUGE step forward! This is promising, because at reasonable dosages (and it’s all about dosage frankly like with any substance) SARMs can be very beneficial, and not just to get in great shape, but for instance in helping bone density by diseases like osteoporosis. One substantial advantage of even the first-generation SARMs developed to date is that they are all orally active without causing liver damage.
S4 (Andarine) is also pretty well – researched, but we will discuss that later, why we did not decide to add it into inex.life.
Discovery AND Therapeutic Promise of SARMs
Just like any other substances, SARMs were not developed for bodybuilders. They have been developed with much more noble impetus.
Androgens have a potential to remedy health issues connected to bone mass density, creation of muscle fiber, spermatogenesis, there are cancer studies. I am sure we are all aware what a terrible conditions can diseases osteoporosis or muscle atrophies bring to the living conditions of an individual. SARMs as nonsteroidal AR ligands are known to act as full agonists in anabolic organs (e.g., muscle and bone) but as partial agonists in androgenic tissues (e.g., prostate and seminal vesicles). Research is going to the point where SARMs would act as a full bone and muscle agonists (chemical that binds to receptor), but without a bind to androgenic tissues. Ostarine or LGD 4033 are promising in this research. We have talked briefly about clinical use limitations of steroids – hepatic, prostate, decrease of HDL cholesterol to just name few.
Compounds that demonstrated higher anabolic activity than androgenic activity in vivo were identified as selective androgen receptor modulators (SARMs). The ultimate goal of research in this field is to discover chemical compounds that can be used for androgen replacement therapy to address one or some functions of prototypic steroidal androgens without unwanted side-effects.
To therapeutic Promise of SARMs belong:
- Treatment of Muscle Wasting
- Prevention and Treatment of Osteoporosis
- Hormonal Male Contraception
- Treatment and Prevention of Benign Prostate Hyperplasia
So what do we know so far
SARMs hold promise as a new class of function promoting anabolic therapies for a number of clinical indications, including functional limitations associated with aging and chronic disease, frailty, cancer cachexia, and osteoporosis.
Two general approaches have historically been used to achieve tissue selectivity of androgen action. The first approach is to develop SARMs with the desired activity profile and tissue selectivity. The second approach is to elucidate the mechanisms of androgen action on the skeletal muscle and the prostate and to identify signaling molecules that are downstream of androgen receptor and which activate pathways involved in skeletal muscle hypertrophy, but not the prostate. Structurally, SARMs can be categorized into steroidal and nonsteroidal SARMs. The steroidal SARMs are formed by modifying the chemical structure of testosterone molecule. Steroidal SARMs do not interest us. SARMs that are of interest for this blog are non-steroidal, usually proteins.
Pioneering efforts by scientists at Ligand Pharmaceuticals and the University of Tennessee provided the early foundations of the nonsteroidal SARM discovery. Since then, a number of structural categories of SARM pharmacophores have been explored: aryl-propionamide (GTX, Inc.), bicyclic hydantoin (BMS), quinolinones (Ligand Pharmaceuticals), tetrahydroquinoline analogs (Kaken Pharmaceuticals, Inc.),
Structural modifications of aryl propionamide analogs bicalutamide and hydroxyflutamide led to the discovery of the first generation of SARMs. Compounds S1 and S4 in this series bind AR with high affinity, and demonstrate tissue selectivity in the Hershberger assay that utilizes castrated rat model. However S1 and S4 are partial agonists. That is why we have decided not to add S4 into our offer. In our opinion S4 is less potent than Ostarine (MK – 667, YK – 2866), or LGD 4033 for the purposes of muscle and bone mass density enhancing. Partial agonists are however also some anti – androgenic drugs used for benign prostatic hyperplasia (enlarged prostate) like Finasterid. This drug has the ability to shutdown the prostate binders and is commonly used by male patter hair loss.
Wikipedia however states that anti – androgenic effects from S4 are not to be expected…This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH. (Wikipedia). In another words S4 is pro and anti – androgenic in the same substance. We wanted to have only androgen receptor agonist with affinity as high as possible, targeting muscle and bone tissue, with minimal to none effects or prostate and different organs. That is why we chose to list Ostarine and LGD 4033.
Conclusion and our final statement
SARMs have to still researched on humans. So far there have been numerous studies on animals, but human studies lack. They will come, no doubt about it, since the topic is way to lucrative and could potentially help lot of people. Meanwhile bodybuilders market is using “for research only” and use them on a regular basis. I do too and I do not see a problem in that. The gains are way so tempting and negatives bearable, so the substances with the best progression – Ostarine, LGD 4033 are here to be utilized.
Just careful, responsible as always. 8 Week cycle with minimal side effects can bring you physical shape you always dreamed of. And you will great about this accomplishment.
1. Discovery AND Therapeutic Promise OF Selective Androgen Receptor Modulators || https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072877/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907129/ Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies
3. Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907129/
4. Novel, non-steroidal, selective androgen receptor modulators (SARMs) with anabolic activity in bone and muscle and improved safety profile. https://www.ncbi.nlm.nih.gov/pubmed/15758439